The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation
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چکیده
منابع مشابه
Centrosome-independent mitotic spindle formation in vertebrates
BACKGROUND In cells lacking centrosomes, the microtubule-organizing activity of the centrosome is substituted for by the combined action of chromatin and molecular motors. The question of whether a centrosome-independent pathway for spindle formation exists in vertebrate somatic cells, which always contain centrosomes, remains unanswered, however. By a combination of labeling with green fluores...
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The centrosome plays a pivotal role in a wide range of cellular processes and its dysfunction is causally linked to many human diseases including cancer and developmental and neurological disorders. This organelle contains more than one hundred components, and yet many of them remain uncharacterised. Here we identified a novel centrosome protein Wdr8, based upon the structural conservation of t...
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Precise positioning of the mitotic spindle determines the correct cell division axis and is crucial for organism development. Spindle positioning is mediated through a cortical machinery by capturing astral microtubules, thereby generating pushing/pulling forces at the cell cortex. However, the molecular link between these two structures remains elusive. Here we describe a previously uncharacte...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2017
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb3486